MONACO - Eight-time defending champion Rafael Nadal extended his Monte Carlo Masters winning streak to 44 matches by defeating Philipp Kohlschreiber 6-2, 6-4 Thursday, while second-ranked Andy Murray was routed 6-1, 6-2 by Stanislas Wawrinka in the third round.
Top-ranked Novak Djokovic put his sore right ankle to the test again, rallying from a set down for the second straight match to beat Juan Monaco of Argentina 4-6, 6-2, 6-2.
"I'm not physically out there feeling my best," Djokovic said. "(It) somehow feels that I always miss that half a step, you know. But I'm trying. I'm fighting. After I lost the first set today, I tried to find that inner strength. I found it again."
Stanislas Wawrinka plays a return to Andy Murray during their match Thursday.
Djokovic will play Jarkko Nieminen in the quarterfinals after the Finn edged Juan Martin del Potro of Argentina 6-4, 4-6, 7-6 (4).
Nieminen sealed victory on his second match point when del Potro sent a big forehand wide. Both players dropped serve five times.
Murray also dropped serve five times and made a number of unforced errors. He lasted less than an hour against the 13th-seeded Wawrinka, who had won their two only previous meetings on clay.
At The Monte-Carlo Country Club
Monte Carlo, Monaco
Purse: $3.93 million (Masters 1000)
Jo-Wilfried Tsonga (6), France, def. Jurgen Melzer, Austria, 6-3, 6-0.
Fabio Fognini, Italy, def. Tomas Berdych (4), Czech Republic, 6-4, 6-2.
Rafael Nadal (3), Spain, def. Philipp Kohlschreiber (16), Germany, 6-2, 6-4.
Grigor Dimitrov, Bulgaria, def. Florian Mayer, Germany, 6-2, 6-4.
Stanislas Wawrinka (13), Switzerland, def. Andy Murray (2), Britain, 6-1, 6-2.
Richard Gasquet (7), France, def. Marin Cilic (9), Croatia, 7-5, 6-4.
Novak Djokovic (1), Serbia, def. Juan Monaco (14), Argentina, 4-6, 6-2, 6-2.
Jarkko Nieminen, Finland, def. Juan Martin del Potro (5), Argentina, 6-4, 4-6, 7-6 (4).
Julien Benneteau, France, and Nenad Zimonjic, Serbia, def. Alexander Peya, Austria, and Bruno Soares (7), Brazil, 7-6 (7), 6-4.
Max Mirnyi, Belarus, and Horia Tecau (5), Romania, def. Ivan Dodig, Croatia, and Radek Stepanek, Czech Republic, 6-2, 6-2.
Jurgen Melzer, Austria, and Leander Paes, India, def. Mahesh Bhupathi and Rohan Bopanna (6), India, 6-2, 6-3.
Aisam-ul-Haq Qureshi, Pakistan, and Jean-Julien Rojer (4), Netherlands, def. Colin Fleming and Jonathan Marray, Britain, 6-4, 6-1.
Milos Raonic, Canada, and Bernard Tomic, Australia, def. Robert Lindstedt (3), Sweden, and Daniel Nestor, Canada, 7-6 (7), 6-3.
Murray was jeered off the court.
Earlier, Nadal dispatched Kohlschreiber without facing a single break point. The Spaniard will face Bulgaria's Grigor Dimitrov in the quarterfinals.
Nadal clipped a forehand winner past Kohlschreiber to break and held at love to move up 5-3 in the second set. He served out the match, clinching victory when the German scooped a backhand into the net.
Djokovic skipped with delight after the 14th-seeded Monaco sent a return long on match point. The Serb had twisted his right ankle on Davis Cup duty against the United States a little less than two weeks ago and had been doubtful to play at Monte Carlo, where he lost to Nadal in last year's final.
Djokovic had a lengthy chat with a trainer at the end of the first set and decided to keep playing. He went up a break early in the second set and held for 3-0. He'll play either fifth-seeded Jarkko Nieminen, of Finland, in the quarterfinals.
Jo-Wilfried Tsonga also advanced with a 6-3, 6-0 win against Jurgen Melzer, breaking the Austrian player four times. Tomas Berdych again struggled with his serve and lost 6-4, 6-2 to Italian Fabio Fognini.
"It's difficult to assess my game because he was not really playing his best," Tsonga said. "But I'm happy I was able to do the job. When you play tennis, you always try for perfection."
Fognini will play seventh-seeded Richard Gasquet, who defeated Marin Cilic 7-5, 6-4.