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Obese Cancer Patients Often Shorted on Chemo Doses

September 30, 2013
By MARILYNN MARCHIONE, AP Chief Medical Writer , The Intelligencer / Wheeling News-Register

Obese people are less likely to survive cancer, and one reason may be a surprising inequality: The overweight are undertreated.

Doctors often short them on chemotherapy by not basing the dose on size, as they should. They use ideal weight or cap the dose out of fear about how much treatment an obese patient can bear. Yet research shows that bigger people handle chemo better than smaller people do.

Even a little less chemo can mean worse odds of survival, and studies suggest that as many as 40 percent of obese cancer patients have been getting less than 85 percent of the right dose for their size.

Article Photos

Tracy Smith looks out of a window at the infusion center at Duke Cancer Center in Durham, N.C. Smith was
treated at Duke in 2011 for breast cancer that had spread to more than a dozen lymph nodes.

AP Photo

Now, the largest organization of doctors who treat cancer, the American Society of Clinical Oncology, aims to change that. The group has adopted guidelines urging full, weight-based doses for the obese.

Don't call it supersizing; it's right-sizing cancer care, said Dr. Gary Lyman, a Duke University oncologist who led the panel that wrote the advice.

"There's little doubt that some degree of undertreatment is contributing to the higher mortality and recurrence rates in obese patients," he said.

The Food and Drug Administration's cancer drug chief, Dr. Richard Pazdur, agrees.

"By minimizing the dose, or capping the dose, we have been undertreating patients," he said.

The dosing issue applies to all types of cancer treated with chemo - breast, colon, lung, ovarian and even blood diseases such as leukemia.

It affects a lot of people. Big isn't healthy but it's the new "normal" - 60 percent of Americans are overweight and more than one-third of them are obese.

Giving too little chemo "could make it as if they didn't even get treated at all ... so they go through the whole ordeal with no benefit, in the extreme case ," said Dr. Jennifer Griggs, a University of Michigan breast cancer specialist who also worked on the guidelines.

So why do doctors limit dose?

Sometimes it's for good reason - the patient has diabetes, heart problems or other illnesses that interfere with how much chemo they can stand. Usually, though, it's because doctors are afraid to follow a standard weight-based formula because the dose seems so huge and they're afraid of harming the heart and blood system, Lyman said.

"You're three times the size of the average person, but it doesn't mean your heart is," Griggs explained.

Yet studies show that heavier patients are less likely to develop dangerous, low blood counts from cancer treatment, and that they clear chemo drugs more quickly from the body than thinner people do.

 
 

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