WELLSBURG - Madonna led by as many as 16 points early in the third quarter before Brooke rallied to within four late in the game.
In the end, Monica Bragg delivered some clutch free-throw shooing down the stretch as the Blue Dons held on to defeat the Bruins.
Bragg recorded a team-high 19 points, including a 9 of 10 showing from the foul line in the fourth quarter.
Angela Staffileno finished with a game-high 25 points to lead the way for the Bruins.
Isabella Preston and Michaela Hinerman each netted five points.