Chiefs Edge Bucs, 27-24
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TAMPA, Fla. (AP) -- Patrick Mahomes threw for 462 yards and three touchdowns to outplay Tom Brady and lead Kansas City past Tampa Bay, 27-24 Sunday.
Tyreek Hill scored on receptions of 75, 44 and 20 yards, backflipping into the end zone on his second TD, and finishing with 13 catches for 269 yards -- the last an 8-yard catch on third-and-7 to give Mahomes an opportunity to run out the clock.
The Chiefs (10-1) won their sixth straight game and clinched their seventh 10-win season in eight years under coach Andy Reid.
The reigning Super Bowl champions improved to 6-0 on the road and have won nine straight away from home going back to last year.
TITANS 45, COLTS 26
INDIANAPOLIS (AP) -- Derrick Henry battered the NFL's second-stingiest defense for 140 yards and three touchdowns in the first half, finished with 178 yards and led the Tennessee Titans to a crucial rout of the Indianapolis Colts.
The win gives Tennessee (8-3) sole possession of the AFC South lead, a split in the two-game season series and a tiebreaking edge based on current division records of the teams.
VIKINGS 28
PANTHERS 27
MINNEAPOLIS (AP) -- Chad Beebe caught a 10-yard touchdown pass with 46 seconds left for Minnesota shortly after he muffed a punt that let Carolina pad its lead. Then Joey Slye missed a 54-yard field goal try with 1 second remaining that preserved the Vikings' victory.
Kirk Cousins went 34 for 45 for 307 yards and three scores for the Vikings (5-6), hitting Justin Jefferson for his second touchdown grab with 5:38 to go and finding Beebe for the winner to punctuate a seven-play, 75-yard drive that took 65 seconds.
PATRIOTS 20
CARDINALS 17
FOXBOROUGH, Mass. (AP) -- Nick Folk kicked a 50-yard field goal as time expired and New England rallied in the second half to beat Arizona.
James White rushed for two touchdowns for the Patriots (5-6).
49ERS 23, RAMS 20
INGLEWOOD, Calif. (AP) -- Robbie Gould made a 42-yard field goal as time expired and the San Francisco snapped its three-game losing streak, sweeping the season series against Los Angeles for the second straight year.
Nick Mullens passed for 253 yards and led two late scoring drives in his first victory as a starter since September for the defending NFC champion Niners (5-6), who stoked their flickering playoff hopes and became the first team to beat the Rams (7-4) at new SoFi Stadium.
SAINTS 31
BRONCOS 3
DENVER (AP) -- Taysom Hill's two touchdown runs led New Orleans past Denver, which was thrust into a quarterback quandary when its passers failed to wear masks as mandated by the NFL's COVID-19 protocols.
In a grind-it-out slugfest reminiscent of pro football's early days, the Saints (9-2) won their second straight game with Hill subbing for the injured Drew Brees.
FALCONS 43
RAIDERS 6
ATLANTA (AP) -- Deion Jones returned an interception 67 yards for a touchdown, Matt Ryan threw a pair of short scoring passes, and Atlanta Falcons thoroughly dominated Derek Carr and bumbling Las Vegas.
The Raiders (6-5) lost their second in a row and looked very much like a pretender in the AFC playoff race, producing a listless, mistake-filled performance against an Atlanta team that's playing out the season under an interim coach.
DOLPHINS 20
JETS 3
EAST RUTHERFORD, N.J. (AP) -- Ryan Fitzpatrick threw two touchdown passes while starting in place of the injured Tua Tagovailoa and Miami kept New York winless.
Tagovailoa was inactive with a left thumb injury, so Fitzpatrick stepped in against one of his many former teams.
BILLS 27
CHARGERS 17
ORCHARD PARK, N.Y. (AP) -- Tre'Davious White's fourth-quarter interception set up Tyler Bass' 43-yard field goal, helping Buffalo hold off Los Angeles.
Josh Allen threw for a touchdown and ran for another score for the AFC East-leading Bills (8-3), who hung on after nearly blowing an 18-point third-quarter lead.
GIANTS 19
BENGALS 17
CINCINNATI (AP) -- New York lost starting quarterback Daniel Jones to a hamstring injury in the second half but generated enough offense to beat Cincinnati.
Jones went down after completing a short pass in the third quarter with the game tied at 10. He returned for two plays on the next series but then was relieved by backup Colt McCoy, who played the rest of the game.
PACKERS 41
BEARS 25
GREEN BAY, Wis. (AP) -- Aaron Rodgers threw four touchdown passes and the Green Bay Packers beat the slumping Chicago Bears to pad their NFC North lead.
Green Bay (8-3) scored touchdowns on each of its first three possessions and grabbed a three-game division edge over Chicago (5-6) and Minnesota. Since winning five of their first six games, the Bears have dropped five straight.